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Type 2 diabetes Reprograms Bone Marrow Hematopoiesis and Dysregulates Immune Signaling in Response to Stroke

2025-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Type 2 diabetes mellitus (T2DM) worsens stroke outcomes, but the underlying mechanisms linking T2DM to systemic immune dysfunction remain unclear. We investigated whether T2DM alters bone marrow (BM) hematopoiesis and dysregulate immune signaling following ischemic stroke in mice. Single-cell RNA sequencing, GeoMx digital spatial profiling (DSP), nCounter, and flow cytometry were used to analyze...

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Literature Corpus work
80b8688b-a983-531d-950d-0a43e4212e9a
DOI
10.64898/2025.12.29.696958
Open publication

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Type 2 diabetes Reprograms Bone Marrow Hematopoiesis and Dysregulates Immune Signaling in Response to StrokeDOI 10.64898/2025.12.29.696958
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