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Article

Diabetes Induces a Transcriptional Signature in Bone Marrow-Derived CD34+ Hematopoietic Stem Cells Predictive of Their Progeny Dysfunction.

International journal of molecular sciences - 31 Jan 2021

D'Alessandra Yuri, Chiesa Mattia, Vigorelli Vera, Ricci Veronica, Rurali Erica, Raucci Angela, Colombo Gualtiero Ivanoe, Pompilio Giulio, Vinci Maria Cristina

Abstract excerpt

Hematopoietic stem/progenitor cells (HSPCs) participate in cardiovascular (CV) homeostasis and generate different types of blood cells including lymphoid and myeloid cells. Diabetes mellitus (DM) is characterized by chronic increase of pro-inflammatory mediators, which play an important role in the development of CV disease, and increased susceptibility to infections. Here, we aimed to evaluate the impact of DM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33572602
DOI: 10.3390/ijms22031423
PMCID: PMC7866997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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