Article

Cellular Senescence and Senescence-Associated Secretory Phenotype Drive Multipotent Cardiac Stem/Progenitor Cell Dysfunction in Human Diabetic Cardiomyopathy Independently of Age

2021-08-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Aging and Diabetes Mellitus (DM) independently and additively increase cardiovascular risk and a pathophysiological basis for this epidemiological link is currently the subject of intense investigations. Both aging and DM affect the biology and regenerative potential of tissue specific cardiac adult stem/progenitor cells (CSCs). In aged subjects over half of the...

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Literature Corpus work: 8bbdbc4b-3a5e-5887-bf92-bab4b9ad7e77
DOI: 10.21203/rs.3.rs-607324/v1

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