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Deconvoluting single-cell transcriptomics reveals cellular programs regulated by cell-cell communication in colorectal cancer

2025-04-15

Abstract excerpt

Cells within a tissue microenvironment communicate through intricate cell-cell communication (CCC) networks. In this meta-analysis of eight single-cell cohorts encompassing 153 patients and 279 samples, we advance the understanding of CCC networks in colorectal cancers through a novel analytical framework. Employing hierarchical topic modeling, we identify gene expression modules (GEMs) that mirror single-cell sig...

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Literature Corpus work
d7b2d6cb-7bec-5b2d-8065-ea94f5fcf29a
DOI
10.1101/2025.04.09.648030
Open publication

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Deconvoluting single-cell transcriptomics reveals cellular programs regulated by cell-cell communication in colorectal cancerDOI 10.1101/2025.04.09.648030
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