Article

An individualized causal framework for learning intercellular communication networks that define microenvironments of individual tumors

2021-11-12

Abstract excerpt

Cells within a tumor microenvironment (TME) dynamically communicate and influence each other’s cellular states through an intercellular communication network (ICN). In cancers, intercellular communications underlie immune evasion mechanisms of individual tumors. We developed an individualized causal analysis framework for discovering tumor-specific ICNs. Using head and neck squamous cell carcinoma (HNSCC) tumors a...

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Literature Corpus work: 5a81a775-d124-5147-84ca-6cbf70f3fc23
DOI: 10.1101/2021.11.11.467838

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