Article

Structural dynamics of adenine nucleotide potentiation of the human type 2 IP <sub>3</sub> receptor

2026-01-24

Abstract excerpt

Inositol trisphosphate receptors (IP 3 R) are intracellular calcium (Ca 2+ ) channels that mediate Ca 2+ flux from the endoplasmic reticulum (ER) into the cytosol, playing a critical role in Ca 2+ signaling. IP 3 R activity requires IP 3 and Ca 2+ and is potentiated by adenine nucleotides through a poorly understood mechanism. Here, we combined single-particle cryo-electron microscopy and all-atom molecular...

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Literature Corpus work: d7b01d4b-f00d-55e5-a213-cc7a485a0170
DOI: 10.64898/2026.01.23.700653

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