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p53 maintains lineage fidelity during lung capillary injury-repair in neonatal hyperoxia

5 Aug 2025

Abstract excerpt

Bronchopulmonary dysplasia (BPD), a prevalent and chronic lung disease affecting premature newborns, results in vascular rarefaction and alveolar simplification. Although the vasculature has been recognized as a main player in this disease, the recently found capillary heterogeneity and cellular dynamics of endothelial subpopulations in BPD remain unclear. Here, we showed that Cap2 cells were damaged during...

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PMID: 40763040
DOI: 10.1172/jci.insight.182880

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