Article

A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

2024-11-22

Abstract excerpt

Two anti-transferrin receptor (TfR) nanobodies, V H H123 specific for mouse TfR and V H H188 specific for human TfR (huTfR) were used to track transplants non-invasively by PET/CT in mouse models, without the need for genetic modification of the transferred cells. We provide a comparison of the specificity and kinetics of the PET signals acquired when using nanobodies radiolabeled with 89 Zr, 64 Cu and 18 F,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d7999fe6-7d2f-52b3-96fd-74537c480632
DOI: 10.1101/2024.11.20.624506

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodiesDOI 10.1101/2024.11.20.624506Read

Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging.Semantic proximity Read

Multi-scale in vivo imaging of tumour development using a germline conditional triple-reporter systemSemantic proximity Read

89 Zr-oxine labelling and PET imaging shows lung delivery of a cell/gene cancer therapySemantic proximity Read

A Genetically Engineered Reporter System Designed for 2H-MRI Allows Quantitative In Vivo Mapping of Transgene ExpressionSemantic proximity Read

In vivo tracking of ex vivo generated 89 Zr-oxine labeled plasma cells by PET in a non-human primate modelSemantic proximity Read

64 Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PETSemantic proximity Read

Humanized TfR1 and transferrin gene-replacement rats for in vivo evaluation of BBB transportSemantic proximity Read

Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene.Semantic proximity Read

Targeting mutant p53: Evaluation of novel anti-p53 R175H monoclonal antibodies as diagnostic toolsSemantic proximity Read

The use of gene-manipulated mice in the validation of receptor binding radiotracer.Semantic proximity Read

Radionuclide selection influences imaging outcomes in immunoPET with a brain-penetrant anti-Aβ antibodySemantic proximity Read

Comparative Analysis of T Cell Imaging with Human Nuclear Reporter Genes.Semantic proximity Read