Article

Humanized TfR1 and transferrin gene-replacement rats for in vivo evaluation of BBB transport

2025-07-31

Abstract excerpt

The transferrin receptor 1 (TfR1)–transferrin (TF) axis plays a central role in iron homeostasis and has long been recognized as a promising route for delivering biologics across the blood–brain barrier (BBB). We have developed a class of human-specific anti-TfR1 nanobodies (NewroBus) that exploit this transport pathway. However, the lack of cross-reactivity with rodent TfR1 limits the utility of standard animal m...

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Identifiers and source

Literature Corpus work: b99c2dbe-03b9-5baa-b616-708840837b54
DOI: 10.1101/2025.07.25.666792

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