Article

<i>In vivo</i> tracking of <i>ex vivo</i> generated <sup>89</sup> Zr-oxine labeled plasma cells by PET in a non-human primate model

2024-05-30

Abstract excerpt

B cells are an attractive platform for engineering to produce protein-based biologics absent in genetic disorders, and potentially for the treatment of metabolic diseases and cancer. As part of pre-clinical development of B cell medicines, we demonstrate a method to collect, ex vivo expand, differentiate, radioactively label, and track adoptively transferred non-human primate (NHP) B cells. These cells underwent...

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Literature Corpus work: 3b034d80-f1d4-5830-b15e-8b90bcf05523
DOI: 10.1101/2024.05.24.595782

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