Article

Targeting mutant p53: Evaluation of novel anti-p53 R175H monoclonal antibodies as diagnostic tools

2024-09-26

Abstract excerpt

<title>Abstract</title> <p>About 50 % of all cancers carry a mutation in p53 that impairs its tumor suppressor function. The p53 missense mutation p53R175H (p53R172H in mice) is a hotspot mutation in cancer and the germline of Li-Fraumeni syndrome patients. Therefore, monoclonal antibodies selectively targeting clinically relevant mutations like p53R175H could prove immensely value. We aimed to evaluate the in vi...

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Literature Corpus work: 0bfd2f7d-bbe6-5343-b394-748c57c2123a
DOI: 10.21203/rs.3.rs-4907916/v1

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