Article
<sup>89</sup> Zr-oxine labelling and PET imaging shows lung delivery of a cell/gene cancer therapy
2019-08-22
Abstract excerpt
<h4>Purpose</h4> MSCTRAIL is a new stem cell-based therapy for lung cancer, currently in phase I evaluation (ClinicalTrials.gov ref: NCT03298763 ). Biodistribution of cell therapies is rarely assessed in clinical trials, despite cell delivery to the target site often being critical to presumed mechanism of action. This preclinical study demonstrates that MSCTRAIL biodistribution dynamics can be detected non-inva...
Topics
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- CAR-T cell therapy research
- Extracellular vesicles in disease
- Medical Imaging Techniques and Applications
- Mesenchymal stem cell research
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
Identifiers and source
- Literature Corpus work
- b6b481c2-c7e0-5cc2-b8bc-7cae6d64f843
- DOI
- 10.1101/736967
