Article

Purine nucleotide limitation undermines antibiotic action in clinical <i>Escherichia coli</i>

2023-06-22

Abstract excerpt

Metabolic variation across pathogenic bacterial strains can impact their susceptibility to antibiotics 1–4 and promote evolution of antimicrobial resistance (AMR) 5,6 . However, little is known about which metabolic pathways contribute to AMR, and the underlying mechanisms. Here, we measured antibiotic resistance of 15,120 Escherichia coli mutants, each with a single amino acid change in one of 346 essential pr...

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Literature Corpus work: d790fff5-4b19-53fa-a7e4-2e039cde9c96
DOI: 10.1101/2023.06.22.546106

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