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Article

Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks.

Molecular systems biology - 1 Mar 2025

Lubrano Paul, Smollich Fabian, Schramm Thorben, Lorenz Elisabeth, Alvarado Alejandra, Eigenmann Seraina Carmen, Stadelmann Amelie, Thavapalan Sevvalli, Waffenschmidt Nils, Glatter Timo, Hoffmann Nadine, Müller Jennifer, Peter Silke, Drescher Knut, Link Hannes

Abstract excerpt

Metabolic variation across pathogenic bacterial strains can impact their susceptibility to antibiotics and promote the evolution of antimicrobial resistance (AMR). However, little is known about how metabolic mutations influence metabolism and which pathways contribute to antibiotic susceptibility. Here, we measured the antibiotic susceptibility of 15,120 Escherichia coli mutants, each with a single amino acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39748127
DOI: 10.1038/s44320-024-00084-z
PMCID: PMC11876631

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