Article

Identification of <i>Escherichia coli</i> Genes Essential for High-Level, Clinically Relevant, Resistance to Antibiotics

2021-11-12

Abstract excerpt

<h4>ABSTRACT</h4> Antibiotic resistance is one of the biggest public health challenges of our time. Here we present a novel approach to recognizing molecular mechanisms essential for maintaining high-level clinically relevant antibiotic resistance. To identify essential genes in this context, we subjected Escherichia coli EV18, a strain highly resistant to quinolones, to random transposon mutagenesis. This strai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b211dcd-ad2c-52ed-9db0-fc01c42f2d29
DOI: 10.1101/2021.11.10.468170

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of <i>Escherichia coli</i> Genes Essential for High-Level, Clinically Relevant, Resistance to AntibioticsDOI 10.1101/2021.11.10.468170Read

The fitness landscape of the mobilized colistin resistance gene <i>mcr-1</i>Semantic proximity Read

High-Throughput Evolution Unravels Landscapes of High-Level Antibiotic Resistance Induced by Low-Level Antibiotic ExposureSemantic proximity Read

Comparative Tn-Seq reveals common daptomycin resistance determinants in <i>Staphylococcus aureus</i> despite strain-dependent differences in essentiality of shared cell envelope genesSemantic proximity Read

From microbial gene essentiality to novel antimicrobial drug targetsSemantic proximity Read

Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon LibrariesSemantic proximity Read

Characterisation of <i>in vitro</i> resistance selection against second-/last-line antibiotics in methicillin-resistant <i>Staphylococcus aureus</i>Semantic proximity Read

<i>Escherichia coli</i> B-strains are intrinsically resistant to colistin and not suitable for characterization and identification of <i>mcr</i> genesSemantic proximity Read

u-CARE: user-friendly Comprehensive Antibiotic resistance Repository of Escherichia coli.Semantic proximity Read

The Secondary Resistome of Methicillin-Resistant Staphylococcus aureus to β-Lactam AntibioticsSemantic proximity Read

Progressive sub-MIC Exposure of <i>Klebsiella pneumoniae</i> 43816 to Cephalothin Induces the Evolution of beta-lactam Resistance without Acquisition of beta-lactamase GenesSemantic proximity Read

Genetic architecture of intrinsic antibiotic susceptibility.Semantic proximity Read

Purine nucleotide limitation undermines antibiotic action in clinical <i>Escherichia coli</i>Semantic proximity Read