Article

Global response to antibiotic exposure uncovers a critical role for nucleotide metabolism in high-level β-lactam tolerance

2025-10-14

Abstract excerpt

<title>Abstract</title> Antibiotic tolerance, the ability to survive lethal antibiotics for a prolonged period of time is a rising threat due to its role as a steppingstone towards antibiotic resistance. While tolerance has been recognized as a severe clinical threat, little is known about the mechanisms promoting tolerance. Here, we delineated the physiology of antibiotic tolerance to the classic β-lactam ant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1fe6821f-756a-576a-bfff-0c16ed59262f
DOI: 10.21203/rs.3.rs-7829012/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Global response to antibiotic exposure uncovers a critical role for nucleotide metabolism in high-level β-lactam toleranceDOI 10.21203/rs.3.rs-7829012/v1Read

Disrupting central carbon metabolism increases antibiotic susceptibility in Vibrio choleraeSemantic proximity Read

Disrupting Central Carbon Metabolism Increases β-Lactam Antibiotic Susceptibility in Vibrio cholerae.Semantic proximity Read

A genome-wide atlas of antibiotic susceptibility targets and pathways to toleranceSemantic proximity Read

Unraveling bacterial stress responses: implications for next-generation antimicrobial solutionsSemantic proximity Read

Peptidoglycan recycling contributes to outer membrane integrity and carbapenem tolerance in Acinetobacter baumanniiSemantic proximity Read

Sugar phosphate-mediated inhibition of peptidoglycan precursor synthesisSemantic proximity Read

Non-essential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stressSemantic proximity Read

Epigenetic modifications and metabolic gene mutations drive resistance evolution in response to stimulatory antibiotics.Semantic proximity Read

Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivitySemantic proximity Read

Revealing Transcriptomic Responses in Escherichia coli During Early Antibiotic ExposureSemantic proximity Read

The classification of bacterial survival strategies in the presence of antimicrobials.Semantic proximity Read