Article
Clinically relevant mutations in core metabolic genes confer antibiotic resistance.
Science (New York, N.Y.) - 19 Feb 2021
Lopatkin Allison J, Bening Sarah C, Manson Abigail L, Stokes Jonathan M, Kohanski Michael A, Badran Ahmed H, Earl Ashlee M, Cheney Nicole J, Yang Jason H, Collins James J
Abstract excerpt
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is generally associated with drug target modification, enzymatic inactivation, and/or transport rather than metabolic processes. Evolution experiments of Escherichia coli rely on growth-dependent selection, which may provide a limited view of the antibiotic resistance landscape. We sequenced and analyzed E. coli adapted to...
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