Article

Cdon suppresses Vascular Smooth Muscle Calcification via Repression of Wnt/Runx2 axis

2022-06-22

Abstract excerpt

Osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) is a risk factor associated with vascular diseases. Wnt signaling is one of the major mechanisms implicated in osteogenic conversion of VSMCs. Since Cdon plays a negative role in Wnt signaling in distinct cellular processes, we sought to investigate the role of Cdon in vascular calcification. The expression of Cdon is significantly downregulat...

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Literature Corpus work: d7869875-b1a3-5e14-ada1-06ab7c2413c2
DOI: 10.21203/rs.3.rs-1732835/v1

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