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Article

Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification.

Circulation research - 8 Jul 2016

Fu Yi, Gao Cheng, Liang Ying, Wang Meili, Huang Yaqian, Ma Wei, Li Tuoyi, Jia Yiting, Yu Fang, Zhu Wanlin, Cui Qinghua, Li Yanhui, Xu Qingbo, Wang Xian, Kong Wei

Abstract excerpt

RATIONALE: Intimal calcification is highly correlated with atherosclerotic plaque burden, but the underlying mechanism is poorly understood. We recently reported that cartilage oligomeric matrix protein (COMP), a component of vascular extracellular matrix, is an endogenous inhibitor of vascular smooth muscle cell calcification. OBJECTIVE: To investigate whether COMP affects atherosclerotic calcification. METHODS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27151399
DOI: 10.1161/CIRCRESAHA.115.308021

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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