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Article

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

5 Oct 2022

Abstract excerpt

Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide, develops almost exclusively in patients with chronic liver disease and advanced fibrosis1,2. Here we interrogated functions of hepatic stellate cells (HSCs), the main source of liver fibroblasts3, during hepatocarcinogenesis. Genetic depletion, activation or inhibition of HSCs in mouse models of HCC revealed their overall...

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PMID: 36198802
DOI: 10.1038/s41586-022-05289-6

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