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The chromatin remodeling protein BRG1 regulates HSC-myofibroblast differentiation and liver fibrosis

14 Dec 2023

Abstract excerpt

Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage liver diseases as hepatocellular carcinoma and cirrhosis. Myofibroblasts, derived primarily from hepatic stellate cells (HSCs), are the effector of liver fibrosis. In the present study we investigated the mechanism by which Brahma-related gene 1 (BRG1, encoded by Smarca4) regulates HSC-myofibroblast...

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PMID: 38092723
DOI: 10.1038/s41419-023-06351-5

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