Article

Targeting EIF5A improves liver fibrosis by inhibiting mitochondrial function of hepatic stellate cells

2023-05-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Liver fibrosis (LF) is the pathological basis of a majority of chronic liver diseases, characterized by excessive activation of hepatic stellate cells (HSCs), inflammatory disorders and progressive scarring of the hepatic interstitial. Recently, sing-cell RNA sequencing (scRNA-seq) technology highlighted a much greater diversity between quiescent HSCs (qHSCs) an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 209da6dc-51ce-51ae-89f0-f21bf33d38a3
DOI: 10.21203/rs.3.rs-2832582/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting EIF5A improves liver fibrosis by inhibiting mitochondrial function of hepatic stellate cellsDOI 10.21203/rs.3.rs-2832582/v1Read

Decoding liver fibrogenesis with single-cell technologiesSemantic proximity Read

Regulatory long non‑coding RNAs of hepatic stellate cells in liver fibrosis (Review)Semantic proximity Read

Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapySemantic proximity Read

Suppressing circ_0008494 inhibits HSC s activation by regulating the miR-185-3p/ Col1a1 axisSemantic proximity Read

Role of noncoding RNAs in liver fibrosisSemantic proximity Read

Alleviation of liver fibrosis by inhibiting a non-canonical ATF4-regulated enhancer program in hepatic stellate cellsSemantic proximity Read

The Roles and Mechanisms of lncRNAs in Liver FibrosisSemantic proximity Read

Targeting Hepatic Stellate Cells for the Prevention and Treatment of Liver Cirrhosis and Hepatocellular Carcinoma: Strategies and Clinical TranslationSemantic proximity Read

Liver Injury and Regeneration: Current Understanding, New Approaches, and Future PerspectivesSemantic proximity Read

Metabolic Reprogramming of Liver FibrosisSemantic proximity Read

An Integrated Single-Cell Atlas Reveals Hepatic Stellate Cell Heterogeneity and Spatiotemporal Dynamics after Liver InjurySemantic proximity Read

Mesenchymal stem cells improve liver fibrosis and protect hepatocytes by promoting microRNA-148a-5p mediated inhibition of Notch signaling pathwaySemantic proximity Read