Article

Cancer pathway connectivity resolved by drug perturbation and RNA sequencing

2025-12-14

Abstract excerpt

Pathway inhibitors are a backbone of cancer treatment. The configuration of pathway dependencies varies from tumour to tumour. Better treatment for individual patients could be designed if the pathway wiring were readily measurable. Here, we characterise the transcriptional responses of 116 lymphoma patient samples exposed to ten drug perturbations. We used factor analysis to decompose individual and shared drug e...

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Literature Corpus work: d7664ee3-0369-5f3e-ad52-e5cb033e9b3b
DOI: 10.64898/2025.12.11.692401

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