Article

Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLL

2021-07-24

Abstract excerpt

The tumour microenvironment and genetic alterations collectively influence drug efficacy in cancer, but current evidence is limited to small scale studies and systematic analyses are lacking. We chose Chronic Lymphocytic Leukaemia (CLL), the most common leukaemia in adults, as a model disease to study this complex interplay systematically. We performed a combinatorial assay using 12 drugs individually co-applied w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 124d2188-0f2b-5e98-b2af-9dde85537834
DOI: 10.1101/2021.07.23.453514

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLLDOI 10.1101/2021.07.23.453514Read

Cancer pathway connectivity resolved by drug perturbation and RNA sequencingSemantic proximity Read

Drug-perturbation-based stratification of blood cancerSemantic proximity Read

Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemiaSemantic proximity Read

Nurture versus Nature: The Microenvironment in Chronic Lymphocytic LeukemiaSemantic proximity Read

Survey of ex vivo drug combination effects in chronic lymphocytic leukemia reveals synergistic drug effects and genetic dependenciesSemantic proximity Read

Exploiting biological diversity and genomic aberrations in chronic lymphocytic leukemiaSemantic proximity Read

Spatial Transcriptomics in Breast Cancer Reveals Tumour Microenvironment-Driven Drug Responses and Clonal Therapeutic HeterogeneitySemantic proximity Read

LINC00152 is a lncRNA modulated by microenvironmental stimuli that has pathogenetic and clinical relevance in CLLSemantic proximity Read

Single-Cell RNA-seq Analysis Reveals Distinct Tumor and Immunosuppressive T-Cell Phenotypes in Patients with CLL Treated with Ibrutinib.Semantic proximity Read

Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies.Semantic proximity Read

Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factorsSemantic proximity Read

CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell LinesSemantic proximity Read