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Network integration of multi-tumour omics data suggests novel targeting strategies

24 Oct 2018

Abstract excerpt

We characterize different tumour types in search for multi-tumour drug targets, in particular aiming for drug repurposing and novel drug combinations. Starting from 11 tumour types from The Cancer Genome Atlas, we obtain three clusters based on transcriptomic correlation profiles. A network-based analysis, integrating gene expression profiles and protein interactions of cancer-related genes, allows us to define...

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PMID: 30375513
DOI: 10.1038/s41467-018-06992-7

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