Article

Specific decreasing of Na <sup>+</sup> channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome

2019-10-16

Abstract excerpt

<h4>ABSTRACT</h4> One phenotypic feature of Brugada syndrome (BrS) is slowed conduction due to the reduction (loss-of-function) of Na + channels. In contrast, recent clinical observations in BrS patients highlighted the poor correlation between the phenotype (typical ECG change or lethal arrhythmia) and the genotype ( SCN5A mutation). Inspired by our previous theoretical study which showed that reduced Na + ch...

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Literature Corpus work: d75cf5f5-ff2d-598b-ac11-5631c481e937
DOI: 10.1101/805986

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