Article
Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease.
American journal of physiology. Heart and circulatory physiology - 1 Jan 2007
Zhang Zhu-Shan, Tranquillo Joseph, Neplioueva Valentina, Bursac Nenad, Grant Augustus O
Abstract excerpt
Some mutations of the sodium channel gene Na(V1.5) are multifunctional, causing combinations of LQTS, Brugada syndrome and progressive cardiac conduction system disease (PCCD). The combination of Brugada syndrome and PCCD is uncommon, although they both result from a reduction in the sodium current. We hypothesize that slow conduction is sufficient to cause S-T segment elevation and undertook a combined...
Topics
- Action Potentials
- Brugada Syndrome
- Cell Line
- Computer Simulation
- Heart Conduction System
- Humans
- Ion Channel Gating
- Kidney
- Kinetics
- Models, Cardiovascular
- Muscle Proteins