Article
From genome to physiome: integrative models of cardiac excitation.
Annals of biomedical engineering - 1 Aug 2000
Rudy Y
Abstract excerpt
The last decade has generated extensive information on the genetic and molecular basis of disease. A major challenge remains the integration of this information into the physiological environment of the functioning cell and tissue. This article illustrates the use of computational biology in meeting this challenge in the context of cardiac excitation and arrhythmia. (1) Genetics to Cell Function: Mutations that...
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