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Article

Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2008

Bébarová Markéta, O'Hara Tom, Geelen Jan L M C, Jongbloed Roselie J, Timmermans Carl, Arens Yvonne H, Rodriguez Luz-Maria, Rudy Yoram, Volders Paul G A

Abstract excerpt

Two mechanisms are generally proposed to explain right precordial ST-segment elevation in Brugada syndrome: 1) right ventricular (RV) subepicardial action potential shortening and/or loss of dome causing transmural dispersion of repolarization; and 2) RV conduction delay. Here we report novel mechanistic insights into ST-segment elevation associated with a Na(+) current (I(Na)) loss-of-function mutation from...

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Identifiers

PMID: 18456723
DOI: 10.1152/ajpheart.91495.2007
PMCID: PMC2494753

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