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Article

Link between SCN5A mutation and the Brugada syndrome ECG phenotype: simulation study.

Circulation journal : official journal of the Japanese Circulation Society - 1 May 2005

Miyoshi Shunichiro, Mitamura Hideo, Fukuda Yukiko, Tanimoto Kojiro, Hagiwara Yoko, Kanki Hideaki, Takatsuki Seiji, Murata Mitsushige, Miyazaki Toshihisa, Ogawa Satoshi

Abstract excerpt

BACKGROUND: The specific changes in the gating kinetics of the sodium current (I(Na)) responsible for its phenotype have remained to be elucidated. In the present study the effect of changes in the gating kinetics of I(Na) on early repolarization (ER) and initiation of phase 2 reentry (P2R) were evaluated in a theoretical epicardial ventricular fiber model. METHODS AND RESULTS: Miyoshi-I(CaL) was incorporated...

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PMID: 15849444
DOI: 10.1253/circj.69.567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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