Article
Cellular and ionic mechanisms responsible for the Brugada syndrome.
Journal of electrocardiology - 1 Jan 2000
Antzelevitch C, Yan G X
Abstract excerpt
The Brugada syndrome is characterized by ST-segment elevation in the right precordial leads, V1-V3 (unrelated to ischemia or structural disease), normal QT intervals, RBBB pattern, and sudden cardiac death, particularly in men of Asian origin. An autosomal dominant mode of inheritance with variable penetrance is generally observed. The only gene mutations thus far linked to the Brugada Syndrome appear in the...
Topics
- Action Potentials
- Bundle-Branch Block
- Death, Sudden, Cardiac
- Electrocardiography
- Humans
- Mutation
- NAV1.5 Voltage-Gated Sodium Channel
- Sodium Channels
- Syndrome
- Ventricular Fibrillation