Role of sodium channels in propagation in heart muscle: how subtle genetic alterations result in major arrhythmic disorders.

Abstract excerpt

Sodium channels play a crucial role in initiation, propagation, and maintenance of cardiac excitation throughout the heart. Indeed, dysfunctional sodium channels have been shown to be responsible for several inherited cardiac electrical disorders, such as Long QT and Brugada syndromes (BrS), potentially leading to fatal arrhythmic events. Genetic approaches and functional experiments using heterologous systems...

Topics

• Action Potentials
• Arrhythmias, Cardiac
• Genetic Predisposition to Disease
• Heart
• Heart Conduction System
• Humans
• Models, Cardiovascular
• Models, Genetic
• Myocardial Contraction
• Sodium Channels
• Structure-Activity Relationship