Article

Reanalysis of Immunopeptidomics Datasets Provides Mechanistic Insight into TAPBPR-Mediated Peptide Editing on HLA-A, -B and -C Molecules

2025-11-25

Abstract excerpt

<h4>Background: </h4> Major histocompatibility class I (MHC-I, human leukocyte antigen [HLA] class I in humans) molecules present small fragments of the proteome on the cell surface for immunosurveillance, which is pivotal to control infected and malignant cells. Immunogenic peptides are generated and selected in the MHC-I antigen processing and presentation pathway. In this pathway, two homologous molecules, tapa...

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Literature Corpus work: d75a1fde-4770-5046-9251-2307687bcc9a
DOI: 10.12688/wellcomeopenres.20738.2

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Reanalysis of Immunopeptidomics Datasets Provides Mechanistic Insight into TAPBPR-Mediated Peptide Editing on HLA-A, -B and -C MoleculesDOI 10.12688/wellcomeopenres.20738.2Read

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