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Article

CryoEM structure of an MHC-I/TAPBPR peptide bound intermediate reveals the mechanism of antigen proofreading

2024-08-07

Abstract excerpt

Class I major histocompatibility complex (MHC-I) proteins play a pivotal role in adaptive immunity by displaying epitopic peptides to CD8+ T cells. The chaperones tapasin and TAPBPR promote the selection of immunogenic antigens from a large pool of intracellular peptides. Interactions of chaperoned MHC-I molecules with incoming peptides are transient in nature, and as a result, the precise antigen proofreading mec...

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Identifiers and source

Literature Corpus work
1a66c6aa-c6e8-5e83-80e5-b02a5a2de7d4
DOI
10.1101/2024.08.05.606663
Open publication

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CryoEM structure of an MHC-I/TAPBPR peptide bound intermediate reveals the mechanism of antigen proofreadingDOI 10.1101/2024.08.05.606663
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