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Article

TAPBPR mediates peptide dissociation from MHC class I using a leucine lever.

eLife - 28 Nov 2018

Ilca F Tudor, Neerincx Andreas, Hermann Clemens, Marcu Ana, Stevanović Stefan, Deane Janet E, Boyle Louise H

Abstract excerpt

Tapasin and TAPBPR are known to perform peptide editing on major histocompatibility complex class I (MHC I) molecules; however, the precise molecular mechanism(s) involved in this process remain largely enigmatic. Here, using immunopeptidomics in combination with novel cell-based assays that assess TAPBPR-mediated peptide exchange, we reveal a critical role for the K22-D35 loop of TAPBPR in mediating peptide...

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Topics

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Share to Antigen Presentation
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-A Antigens

Share to Immunoglobulins

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Share to Molecular Docking Simulation

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Source

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Identifiers

PMID: 30484775
DOI: 10.7554/eLife.40126
PMCID: PMC6307860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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