Article

Discriminating activating, deactivating and resistance variants in protein kinases

2024-09-30

Abstract excerpt

<title>Abstract</title> <p>We present a data-driven approach to predict the functional consequence of genetic changes in protein kinases. We first created a large curated dataset of 375 activating/gain-of-function, 1028 deactivating/loss, 98 resistance and 1004 neutral protein variants in 441 human kinases by scouring the literature and various databases. For any variant, we defined a vector of 7 types of sequenc...

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Literature Corpus work: d7468fa4-4a2a-594b-9c58-95abc54e96b1
DOI: 10.21203/rs.3.rs-5001235/v1

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