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Article

Computational algorithms for in silico profiling of activating mutations in cancer.

Cellular and molecular life sciences : CMLS - 1 Jul 2019

Jordan E Joseph, Patil Keshav, Suresh Krishna, Park Jin H, Mosse Yael P, Lemmon Mark A, Radhakrishnan Ravi

Abstract excerpt

Methods to catalog and computationally assess the mutational landscape of proteins in human cancers are desirable. One approach is to adapt evolutionary or data-driven methods developed for predicting whether a single-nucleotide polymorphism (SNP) is deleterious to protein structure and function. In cases where understanding the mechanism of protein activation and regulation is desired, an alternative approach is...

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Identifiers

PMID: 30982079
DOI: 10.1007/s00018-019-03097-2
PMCID: PMC6589134

Genes

ALK
BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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