Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kin-Driver: a database of driver mutations in protein kinases.

Database : the journal of biological databases and curation - 1 Jan 2014

Simonetti Franco L, Tornador Cristian, Nabau-Moretó Nuria, Molina-Vila Miguel A, Marino-Buslje Cristina

Abstract excerpt

Somatic mutations in protein kinases (PKs) are frequent driver events in many human tumors, while germ-line mutations are associated with hereditary diseases. Here we present Kin-driver, the first database that compiles driver mutations in PKs with experimental evidence demonstrating their functional role. Kin-driver is a manual expert-curated database that pays special attention to activating mutations (AMs) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Databases, Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Molecular Sequence Data

Share to Mutant Proteins

Share to Mutation

Share to Protein Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 25414382
DOI: 10.1093/database/bau104
PMCID: PMC4237945

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kin-Driver: a database of driver mutations in protein kinases.PMID 25414382Read ↗

KinMutBase, a database of human disease-causing protein kinase mutations.Semantic proximity Read ↗

KinMutBase: a registry of disease-causing mutations in protein kinase domains.Semantic proximity Read ↗

KinMutBase, a database of human disease-causing protein kinase mutations.Semantic proximity Read ↗

Prediction of cancer driver mutations in protein kinases.Semantic proximity Read ↗

MoKCa database--mutations of kinases in cancer.Semantic proximity Read ↗

Sequence and structure signatures of cancer mutation hotspots in protein kinases.Semantic proximity Read ↗

KinaseMD: kinase mutations and drug response database.Semantic proximity Read ↗

Integrative machine learning predicts activating kinase mutations for precision oncologySemantic proximity Read ↗

Activating Mutations Cluster in the “Molecular Brake” Regions of Protein Kinases and Do Not Associate with Conserved or Catalytic ResiduesSemantic proximity Read ↗

Cancer-associated mutations are preferentially distributed in protein kinase functional sites.Semantic proximity Read ↗

Comparison of actionable alterations in cancers with kinase fusion, mutation, and amplificationSemantic proximity Read ↗

Mutational Landscape of Cancer-Driver Genes Across Human CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.