Article

CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity

2021-04-30

Abstract excerpt

<h4>Background: </h4> Che-1/AATF (Che-1) is an RNA polymerase II binding protein involved in several cellular processes, including proliferation, apoptosis and response to stress. We have recently demonstrated that Che-1 is able to promote cell proliferation by sustaining global histone acetylation in Multiple Myeloma (MM) cells where it interacts with histone proteins and competes with HDAC class I members for bi...

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Literature Corpus work: d7418b67-eac5-5a4b-9fba-f82e923366d9
DOI: 10.21203/rs.3.rs-459016/v1

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