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C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer

12 May 2021

Abstract excerpt

The activity of histone acetyltransferases (HATs) plays a central role in an epigenetic modification in cooperation with HDACs (histone deacetyl transferases). It is likely that malfunction of this enzymatic machinery controlling epigenetic modification is relevant to carcinogenesis and tumor progression. However, in pancreatic cancer, the clinical relevance of HAT activity and histone acetylation has remained...

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Share to Epigenetics and DNA Methylation
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PMID: 33980911
DOI: 10.1038/s41598-021-89530-8

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