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Targeting the Interplay between HDACs and DNA Damage Repair for Myeloma Therapy

27 Sept 2021

Abstract excerpt

Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells, and accounts for 10% of all hematologic malignancies and 1% of all cancers. MM is characterized by genomic instability which results from DNA damage with certain genomic rearrangements being prognostic factors for the disease and patients' clinical response. Following genotoxic stress, the evolutionary conserved DNA damage response...

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PMID: 34638744
DOI: 10.3390/ijms221910406

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