Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.

Molecular and cellular biology - 15 Jul 2016

Huang Fu, Abmayr Susan M, Workman Jerry L

Abstract excerpt

The lysine acetyltransferase 6 (KAT6) histone acetyltransferase (HAT) complexes are highly conserved from yeast to higher organisms. They acetylate histone H3 and other nonhistone substrates and are involved in cell cycle regulation and stem cell maintenance. In addition, the human KAT6 HATs are recurrently mutated in leukemia and solid tumors. Therefore, it is important to understand the mechanisms underlying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cell Cycle
Share to Histone Acetyltransferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histones

Share to Neoplasms

Share to Neurodevelopmental Disorders

Share to Stem Cells

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 27185879
DOI: 10.1128/MCB.00055-16
PMCID: PMC4936061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.PMID 27185879Read ↗

The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and functionSemantic proximity Read ↗

KAT8 beyond Acetylation: A Survey of Its Epigenetic Regulation, Genetic Variability, and Implications for Human Health.Semantic proximity Read ↗

KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.Semantic proximity Read ↗

Biological Function and Mechanism of NAT10 in CancerSemantic proximity Read ↗

Molecular Basis for Histone Acetyltransferase Regulation by Binding Partners, Associated Domains, and AutoacetylationSemantic proximity Read ↗

Histone deacetylase 6 in cancerSemantic proximity Read ↗

KAT7 is a therapeutic vulnerability of <i>MLL</i> -rearranged acute myeloid leukemiaSemantic proximity Read ↗

De novo nonsense mutations in KAT6A, a lysine acetyl-transferase gene, cause a syndrome including microcephaly and global developmental delay.Semantic proximity Read ↗

Reversible acetylation of chromatin: Implication in regulation of gene expression, disease and therapeuticsSemantic proximity Read ↗

Biological functions of m6A methyltransferasesSemantic proximity Read ↗

Main N6-Methyladenosine Readers: YTH Family Proteins in CancersSemantic proximity Read ↗

Esa1p is an essential histone acetyltransferase required for cell cycle progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.