Article

Genome Wide Pleiotropic Analysis to Identify Novel Variants and Improve Genetic Risk Score Construction

2021-03-10

Abstract excerpt

<title>Abstract</title> <p>Systolic and diastolic blood pressure (S/DBP) are highly correlated and modifiable risk factors for cardiovascular disease (CVD). We report here a bidirectional Mendelian Randomization (MR) and GWAS pleiotropy analysis of S/DBP summary statistics from large published BP GWAS and construct a composite genetic risk score (GRS), capturing respectively 21%, 11%, and 227% more of SBP, DBP an...

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Literature Corpus work: d740572e-b786-5281-91c6-2085cf4206b4
DOI: 10.21203/rs.3.rs-133000/v2

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