Article
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2014
Andreassen Ole A, McEvoy Linda K, Thompson Wesley K, Wang Yunpeng, Reppe Sjur, Schork Andrew J, Zuber Verena, Barrett-Connor Elizabeth, Gautvik Kaare, Aukrust Pål, Karlsen Tom H, Djurovic Srdjan, Desikan Rahul S, Dale Anders M
Abstract excerpt
Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected by environmental factors, but has a strong heritable component. Despite recent large genome-wide association studies, few genetic risk factors for blood pressure have been identified. Epidemiological studies suggest associations between blood pressure and several diseases and traits, which may partly arise from a...
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