Article

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

2025-06-24

Abstract excerpt

<h4>Summary</h4> Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting their application. Although fetal cardiomyocytes in the human heart lose their proliferative potential during maturation and become tetraploid, iPS-CMs cannot replicate this tetraploidization and rem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d721c992-d25f-57f2-ba64-a57b23b1778f
DOI: 10.1101/2025.06.23.661005

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCsDOI 10.1101/2025.06.23.661005Read

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCsSemantic proximity Read

Induced Pluripotent Stem Cells Technology and Cardiomyocyte Generation: Progress, Uncertainties and Challenges in the Biological Features and Clinical ApplicationsSemantic proximity Read

Induced pluripotent stem-cell-derived cardiomyocytes: cardiac applications, opportunities, and challenges.Semantic proximity Read

Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations.Semantic proximity Read

Human Induced Pluripotent Stem-Cell-Derived Cardiomyocytes as Models for Genetic CardiomyopathiesSemantic proximity Read

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.Semantic proximity Read

Generation of two heterozygous MYBPC3 mutation-carrying human iPSC lines, SCVIi001-A and SCVIi002-A, for modeling hypertrophic cardiomyopathy.Semantic proximity Read

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes.Semantic proximity Read

Comparative analysis of the cardiomyocyte differentiation potential of induced pluripotent stem cells reprogrammed from human atrial or ventricular fibroblastsSemantic proximity Read

Induced pluripotent stem cells in the inherited cardiomyopathies: From disease mechanisms to novel therapies.Semantic proximity Read

Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential.Semantic proximity Read

Ion channel expression and electrophysiology of singular human (primary and induced pluripotent stem cell derived) cardiomyocytesSemantic proximity Read