Article
Induced pluripotent stem cells in the inherited cardiomyopathies: From disease mechanisms to novel therapies.
Trends in cardiovascular medicine - 1 Nov 2016
Ross Samantha Barratt, Fraser Stuart T, Semsarian Christopher
Abstract excerpt
Inherited cardiomyopathies lead to diverse clinical outcomes including heart failure, arrhythmias, and sudden death. Mutations in over 100 genes have been implicated in the pathogenesis of genetic heart diseases, including the main inherited cardiomyopathies, such as hypertrophic, dilated, and arrhythmogenic right ventricular cardiomyopathies. Understanding how these gene mutations lead to clinical disease and...
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