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Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

17 Aug 2026

Abstract excerpt

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting their application. Fetal cardiomyocytes in the human heart are diploid and proliferating, but gradually lose their proliferative potential during maturation. Most human cardiomyocytes eventually become tetraploid,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42608426
DOI: 10.1038/s42003-026-10763-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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