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Article

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.

Biochimica et biophysica acta - 1 Jul 2016

Denning Chris, Borgdorff Viola, Crutchley James, Firth Karl S A, George Vinoj, Kalra Spandan, Kondrashov Alexander, Hoang Minh Duc, Mosqueira Diogo, Patel Asha, Prodanov Ljupcho, Rajamohan Divya, Skarnes William C, Smith James G W, Young Lorraine E

Abstract excerpt

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise biomedicine. Global burden of heart failure will soon reach USD $90bn, while unexpected cardiotoxicity underlies 28% of drug withdrawals. Advances in hPSC isolation, Cas9/CRISPR genome engineering and hPSC-CM differentiation have improved patient care, progressed drugs to clinic and opened a new era in safety pharmacology....

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Identifiers

PMID: 26524115
DOI: 10.1016/j.bbamcr.2015.10.014
PMCID: PMC5221745

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