Article

RAStoERK: a reference interaction atlas for insights into signaling and disease

2026-04-09

Abstract excerpt

<h4>Summary</h4> The RAS/RAF/MEK/ERK pathway has been extensively studied for its roles in physiology and disease, yet a systems-level view of its interplay with the broader cellular context is lacking, limiting insight into paralog-specific roles, mutation-driven rewiring, and cross-pathway integration. To address this, we simultaneously mapped the interactomes of all pathway components and their activating and...

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Literature Corpus work: 349632b4-b649-55e9-a3cf-e9d2d6556a6d
DOI: 10.64898/2026.04.07.716061

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