Article
Pathogenic impact of transcript isoform switching in 1209 cancer samples covering 27 cancer types using an isoform-specific interaction network
2019-08-24
Abstract excerpt
Under normal conditions, cells of almost all tissue types express the same predominant canonical transcript isoform at each gene locus. In cancer, however, splicing regulation is often disturbed, leading to cancer-specific switches in the most dominant transcripts (MDT). But what is the pathogenic impact of these switches and how are they driving oncogenesis? To address these questions, we have analyzed isoform-sp...
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Identifiers and source
- Literature Corpus work
- c0bcb074-2516-55af-89ea-0ac476fe6f7f
- DOI
- 10.1101/742379